{"id":123316,"date":"2021-10-04T09:37:27","date_gmt":"2021-10-04T13:37:27","guid":{"rendered":"https:/news/wp-json/wp/v2/posts/123316///news/wp-json/wp/v2/posts/123316//www.ucf.edu/news/wp-json/wp/v2/posts/123316//news/news/wp-json/wp/v2/posts/123316//?p=123316"},"modified":"2025-06-26T09:52:56","modified_gmt":"2025-06-26T13:52:56","slug":"expertise-from-a-breast-cancer-researcher-podcast","status":"publish","type":"post","link":"https:/news/wp-json/wp/v2/posts/123316///news/wp-json/wp/v2/posts/123316//www.ucf.edu/news/wp-json/wp/v2/posts/123316//news/news/wp-json/wp/v2/posts/123316//expertise-from-a-breast-cancer-researcher-podcast/news/wp-json/wp/v2/posts/123316//","title":{"rendered":"UCF Podcast: Expertise from a Breast Cancer Researcher"},"content":{"rendered":"<p>In episode 10 of the 166su podcast, Knights Do That, we speak with&nbsp;Annette Khaled, a 166su <a href=/news/wp-json/wp/v2/posts/123316/"https:/news/wp-json/wp/v2/posts/123316///news/wp-json/wp/v2/posts/123316//med.ucf.edu/news/wp-json/wp/v2/posts/123316///news/wp-json/wp/v2/posts/123316/">College of Medicine</news/wp-json/wp/v2/posts/123316//a> professor and the head of the Division of Cancer Research at 166su. Khaled discusses her expertise on breast cancer research /news/wp-json/wp/v2/posts/123316/u2014 specifically in breast cancer metastases. Khaled shares her personal experiences that drive the passion for her work, the collaborative culture of teamwork, optimism, and humanity at 166su, and some of the biggest mysteries of breast cancer that we/news/wp-json/wp/v2/posts/123316/u2019re still trying to solve.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p>Produced by 166su, the podcast highlights students, faculty, staff, administrators and alumni who do incredible things on campus, in the community and around the globe.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p>&nbsp;</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<figure class=/news/wp-json/wp/v2/posts/123316/"wp-block-audio/news/wp-json/wp/v2/posts/123316/"><noscript><audio 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class=/news/wp-json/wp/v2/posts/123316/"mce_SELRES_start/news/wp-json/wp/v2/posts/123316/"></news/wp-json/wp/v2/posts/123316//span></news/wp-json/wp/v2/posts/123316//audio></news/wp-json/wp/v2/posts/123316//noscript><audio src=/news/wp-json/wp/v2/posts/123316/"https:/news/wp-json/wp/v2/posts/123316///news/wp-json/wp/v2/posts/123316//anchor.fm/news/wp-json/wp/v2/posts/123316//s/news/wp-json/wp/v2/posts/123316//5132f554/news/wp-json/wp/v2/posts/123316//podcast/news/wp-json/wp/v2/posts/123316//play/news/wp-json/wp/v2/posts/123316//41039374/news/wp-json/wp/v2/posts/123316//https%3A%2F%2Fd3ctxlq1ktw2nl.cloudfront.net%2Fstaging%2F2021-9-4%2F7675c3fc-4e81-dc54-990f-e8a835442a19.m4a/news/wp-json/wp/v2/posts/123316/" controls=/news/wp-json/wp/v2/posts/123316/"controls/news/wp-json/wp/v2/posts/123316/" preload=/news/wp-json/wp/v2/posts/123316/"none/news/wp-json/wp/v2/posts/123316/" class=/news/wp-json/wp/v2/posts/123316/" lazyload/news/wp-json/wp/v2/posts/123316/"><span 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data-src=/news/wp-json/wp/v2/posts/123316/"https:/news/wp-json/wp/v2/posts/123316///news/wp-json/wp/v2/posts/123316//www.ucf.edu/news/wp-json/wp/v2/posts/123316//news/news/wp-json/wp/v2/posts/123316//wp-content/news/wp-json/wp/v2/posts/123316//blogs.dir/news/wp-json/wp/v2/posts/123316//20/news/wp-json/wp/v2/posts/123316//files/news/wp-json/wp/v2/posts/123316//2021/news/wp-json/wp/v2/posts/123316//05/news/wp-json/wp/v2/posts/123316//spotify.png/news/wp-json/wp/v2/posts/123316/" class=/news/wp-json/wp/v2/posts/123316/" lazyload/news/wp-json/wp/v2/posts/123316/"></news/wp-json/wp/v2/posts/123316//a></news/wp-json/wp/v2/posts/123316//div>/news/wp-json/wp/v2/posts/123316/n/news/wp-json/wp/v2/posts/123316/t/news/wp-json/wp/v2/posts/123316/t/news/wp-json/wp/v2/posts/123316/t/news/wp-json/wp/v2/posts/123316/t/news/wp-json/wp/v2/posts/123316/t</news/wp-json/wp/v2/posts/123316//section>/news/wp-json/wp/v2/posts/123316/n/news/wp-json/wp/v2/posts/123316/t/news/wp-json/wp/v2/posts/123316/t/news/wp-json/wp/v2/posts/123316/n<h2>Transcript</news/wp-json/wp/v2/posts/123316//h2>/news/wp-json/wp/v2/posts/123316/n<p><strong>Annette Khaled:</news/wp-json/wp/v2/posts/123316//strong> We need to do research to better understand what happens when we don/news/wp-json/wp/v2/posts/123316/u2019t catch cancer early, when a patient now has metastatic cancer that has spread, and can we develop better ways of helping these patients.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p>Because that/news/wp-json/wp/v2/posts/123316/u2019s where death occurs. Death and breast cancer are linked to the cancer spreading. So, understanding that process is essential for research.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Alex Cumming:</news/wp-json/wp/v2/posts/123316//strong> Hey Knight Nation, what an interesting and enlightening conversation that I got to have with Dr. Annette Khaled from 166su/news/wp-json/wp/v2/posts/123316/u2019s College of Medicine. Dr. Khaled is the head of the Division of Cancer Research at 166su and has been recognized for her breast cancer research specifically in breast cancer metastases. In today/news/wp-json/wp/v2/posts/123316/u2019s episode, we speak about the personal experiences that she/news/wp-json/wp/v2/posts/123316/u2019s had that drive the passion for her work, collaborative culture of teamwork, optimism, and humanity here at 166su, and some of the biggest mysteries of breast cancer that we/news/wp-json/wp/v2/posts/123316/u2019re still trying to solve. Let/news/wp-json/wp/v2/posts/123316/u2019s jump into.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p>So to begin, how did your interest with medicine, specifically working with breast cancer, develop?</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Annette Khaled:</news/wp-json/wp/v2/posts/123316//strong> Yeah, that/news/wp-json/wp/v2/posts/123316/u2019s a great question.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p>So my background /news/wp-json/wp/v2/posts/123316/u2014 I/news/wp-json/wp/v2/posts/123316/u2019m a basic scientist. I really don/news/wp-json/wp/v2/posts/123316/u2019t work directly in medicine /news/wp-json/wp/v2/posts/123316/u2014 I ask those basic biology questions. Why do things happen? Years back, I was working to understand how cells die. What causes a cell to die when it/news/wp-json/wp/v2/posts/123316/u2019s happily growing and suddenly all its growth signals go? What/news/wp-json/wp/v2/posts/123316/u2019s happening inside of that cell? And it really was in the process of understanding the molecular events that were happening in these dying cells that led us to discover what could potentially be a therapeutic for cancer. And that/news/wp-json/wp/v2/posts/123316/u2019s how we ended up now jumping into breast cancer and really working on both a therapeutic and a diagnostic for breast cancer. Moving from those basic discoveries to some application in medicine.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Alex Cumming:</news/wp-json/wp/v2/posts/123316//strong> Wow. How cool?</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p>So as of this year, the World Health Organization has found that breast cancer is the most common cancer globally. Can you share with me some of the importance of early screenings for breast cancer, as well as the need for continuous research of the disease?</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Annette Khaled:</news/wp-json/wp/v2/posts/123316//strong> Both those aspects are tied together. So early screening &#8211; cannot emphasize enough the importance. Any cancer, especially breast cancer, if you find it early, when it/news/wp-json/wp/v2/posts/123316/u2019s still inside the breast, it&#8217;s still localized to one place in the breast, it/news/wp-json/wp/v2/posts/123316/u2019s much easier to treat. You can remove it surgically. You can treat it, and outcomes are like 90% or 99% survival. So early screening is essential.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p>And then, why do we have to do research? Well unfortunately, for some people, they don/news/wp-json/wp/v2/posts/123316/u2019t catch it early. Sometimes they catch it when it/news/wp-json/wp/v2/posts/123316/u2019s already showing symptoms and spreading. It may be in the liver, it may be in the brain and the bones. And at that point we don/news/wp-json/wp/v2/posts/123316/u2019t have enough of an understanding about how that happened, why that happened. So we need to do research to better understand what happens when we don/news/wp-json/wp/v2/posts/123316/u2019t catch it early, when a patient now has metastatic cancer that has spread. And then can we develop better ways of helping these patients. Because that/news/wp-json/wp/v2/posts/123316/u2019s when death occurs. Death and breast cancer are linked to that cancer spreading. So understanding that process is essential for research.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Alex Cumming:</news/wp-json/wp/v2/posts/123316//strong> Are there things you can notice within somebody that maybe they should say to themselves, /news/wp-json/wp/v2/posts/123316/u201cI should get checked because I/news/wp-json/wp/v2/posts/123316/u2019m having this symptom or I/news/wp-json/wp/v2/posts/123316/u2019m feeling this sort of lump or I am just feeling off./news/wp-json/wp/v2/posts/123316/u201d</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Annette Khaled:</news/wp-json/wp/v2/posts/123316//strong> Cancer is hidden. Cancer is your own body. It/news/wp-json/wp/v2/posts/123316/u2019s your own tissues, doing bad stuff to you. And so it/news/wp-json/wp/v2/posts/123316/u2019s really hard to wait for symptoms. That/news/wp-json/wp/v2/posts/123316/u2019s why screening is much more important. You should be screening yourself. And there/news/wp-json/wp/v2/posts/123316/u2019s guidelines, you should be screening by a certain age, by a certain risk factors.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p>You can do genetic testing, but it/news/wp-json/wp/v2/posts/123316/u2019s only a portion of cancers that are linked to a genetic outcome. So from my perspective, and it/news/wp-json/wp/v2/posts/123316/u2019s my own personal opinion, I think early screening is the best way. Get your mammograms every year. When you/news/wp-json/wp/v2/posts/123316/u2019re due, get your mammograms. Don/news/wp-json/wp/v2/posts/123316/u2019t wait for the symptoms because sometimes when the symptoms show up, it/news/wp-json/wp/v2/posts/123316/u2019s too late.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Alex Cumming:</news/wp-json/wp/v2/posts/123316//strong> That/news/wp-json/wp/v2/posts/123316/u2019s good to be proactive instead of being forced to be reactive, sort of getting ahead of the curve.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Annette Khaled:</news/wp-json/wp/v2/posts/123316//strong> Exactly.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Alex Cumming:</news/wp-json/wp/v2/posts/123316//strong> What you/news/wp-json/wp/v2/posts/123316/u2019re saying it sounds as though a lot of people are forced to enter that reactive phase due to maybe outside circumstances that prevented them from being proactive on the situation. And when you/news/wp-json/wp/v2/posts/123316/u2019re in that reactive phase, it sounds like you have go all in on focusing on how can I give myself the best opportunity to treat this. And it sounds like from what you/news/wp-json/wp/v2/posts/123316/u2019re saying is that a lot of people don/news/wp-json/wp/v2/posts/123316/u2019t go into this alone. They have these circles in these groups that support them and help them along the way.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p>And as mentioned, breast cancer is one of the most common cancers found globally, support to know that you/news/wp-json/wp/v2/posts/123316/u2019re not alone in this situation, you find that/news/wp-json/wp/v2/posts/123316/u2019s an important /news/wp-json/wp/v2/posts/123316/u2014</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Annette Khaled:</news/wp-json/wp/v2/posts/123316//strong> And not to be /news/wp-json/wp/v2/posts/123316/u2014 it/news/wp-json/wp/v2/posts/123316/u2019s scary, right? You get a cancer diagnosis. I have cancer. /news/wp-json/wp/v2/posts/123316/u201cWhat did I do? Why has this happened to me? Did I do something?/news/wp-json/wp/v2/posts/123316/u201d Disease just happens sometimes. And having support, having an understanding that there are great therapies out there. The survival is so much better now than it was in the past for breast cancer. There/news/wp-json/wp/v2/posts/123316/u2019s lots of treatment options and just get the support you need. You/news/wp-json/wp/v2/posts/123316/u2019re not doing this alone. We have great support systems for breast cancer. So I/news/wp-json/wp/v2/posts/123316/u2019m glad you said that. We can do things if you have, unfortunately, that cancer diagnosis. There are many avenues available.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Alex Cumming:</news/wp-json/wp/v2/posts/123316//strong> My grandmother is a breast cancer survivor, so breast cancer awareness is a very personal topic for me. Of course she had it, I/news/wp-json/wp/v2/posts/123316/u2019m so thankful that she survived, beat it. I was younger, so I wasn/news/wp-json/wp/v2/posts/123316/u2019t fully able to grasp how it affects somebody/news/wp-json/wp/v2/posts/123316/u2019s body, but I saw firsthand how it affects the lives of my own personal family and herself. I/news/wp-json/wp/v2/posts/123316/u2019m so thankful that she lives in Florida, so we/news/wp-json/wp/v2/posts/123316/u2019re able to visit her and to be there for her in this time. And I mean, there/news/wp-json/wp/v2/posts/123316/u2019s just this weight that comes off of just this collective of people when we found out that she had overcome it.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Annette Khaled:</news/wp-json/wp/v2/posts/123316//strong> It/news/wp-json/wp/v2/posts/123316/u2019s beating it that gives you that, /news/wp-json/wp/v2/posts/123316/u201cWow, this is not the end of my life. This is something that happened along my life./news/wp-json/wp/v2/posts/123316/u201d And that/news/wp-json/wp/v2/posts/123316/u2019s what drives the research as well, as being able to advance that. Hopefully to the point where your grandkids will no longer see cancer as a threat. Cancer happens, there/news/wp-json/wp/v2/posts/123316/u2019s treatments. It goes away, we/news/wp-json/wp/v2/posts/123316/u2019re done. And hopefully take that threat from our lives.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Alex Cumming:</news/wp-json/wp/v2/posts/123316//strong> When my grandmother was affected by it, she was in, I believe, late 60s, early 70s. And when she beat it she was in her mid, I believe, mid-70s. So, we have this joke, nothing/news/wp-json/wp/v2/posts/123316/u2019s going to keep her down. Nothing/news/wp-json/wp/v2/posts/123316/u2019s going to stop her from beating breast cancer in her 70s. It was a really just something that you don/news/wp-json/wp/v2/posts/123316/u2019t forget. You don/news/wp-json/wp/v2/posts/123316/u2019t forget that period of your life, where it was in the back of your head. We were like, /news/wp-json/wp/v2/posts/123316/u201cThis could be just any day, this could happen./news/wp-json/wp/v2/posts/123316/u201d</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Annette Khaled:</news/wp-json/wp/v2/posts/123316//strong> So true.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Alex Cumming:</news/wp-json/wp/v2/posts/123316//strong> So to transition from that, and that you spent nearly a decade studying ways to inhibit breast cancer metastases, which happens when cancer spreads to all other parts of the body. What have been some of the most important discoveries that you/news/wp-json/wp/v2/posts/123316/u2019ve found?</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Annette Khaled:</news/wp-json/wp/v2/posts/123316//strong> I think the most important discovery we found, I was telling you earlier that we were studying this death pathway of cells and came up with a therapeutic. Trying to understand how, why the therapeutic was killing, really led us to discover a protein that hadn/news/wp-json/wp/v2/posts/123316/u2019t ever been associated with cancer before. And it/news/wp-json/wp/v2/posts/123316/u2019s a protein that helps other proteins fold &#8211; basically to get the right three-dimensional shape. Proteins have three-dimensional functionalities and so this protein that we found that our therapeutic was targeting was involved in this folding process. That had never been associated with cancer, and especially with metastatic cancer, like you said, the cancer that spread throughout the body. Really finding how this protein was working, how it was contributing to cancer spreading &nbsp;&#8211; that has been probably one of the best discoveries that we have made in the last few years and really drives our research now.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Alex Cumming:</news/wp-json/wp/v2/posts/123316//strong> Seeing that there/news/wp-json/wp/v2/posts/123316/u2019ss these links between parts of the body and how they react when cancer is discovered in the body, is that what you&#8217;re saying?</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Annette Khaled:</news/wp-json/wp/v2/posts/123316//strong> Yes. So you think about cancer when it/news/wp-json/wp/v2/posts/123316/u2019s inside the breast, when it/news/wp-json/wp/v2/posts/123316/u2019s localized, has certain needs, right? , but once the cancer leaves its home in the breast and it travels and it goes through the blood. I mean, the stresses in the blood are horrendous. Most cancer cells die when they hit the bloodstream. But if they do survive, and those that survive need different survival factors than they did when they were in the home, in the breast. And then think of that, they have to now land in a new place, like they end up in the liver and the liver is very different from the breast, and it/news/wp-json/wp/v2/posts/123316/u2019s very different from the blood. They have to learn to adapt to that new environment. So the protein that we/news/wp-json/wp/v2/posts/123316/u2019ve been studying, we think helps those cancer cells do exactly that /news/wp-json/wp/v2/posts/123316/u2014 survive while they/news/wp-json/wp/v2/posts/123316/u2019re in the bloodstream, survive when they get to the new site in the liver to grow and colonize again.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p>That/news/wp-json/wp/v2/posts/123316/u2019s why it/news/wp-json/wp/v2/posts/123316/u2019s of interest to us. Because if what we/news/wp-json/wp/v2/posts/123316/u2019re discovering is true, then we do have a really great target as a therapeutic target for these types of metastatic cancers.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Alex Cumming:</news/wp-json/wp/v2/posts/123316//strong> We spoke about the community aspect of this. Do you find the mental well-being of a patient can be akin to the medical wellbeing?</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Annette Khaled:</news/wp-json/wp/v2/posts/123316//strong> Oh, that is so true. I think just having hope. And I think that/news/wp-json/wp/v2/posts/123316/u2019s part of. I mean I really enjoy interacting and talking, like I am today with you, talking to anybody who interested in what we do. Because I think it gives people hope to know that my laboratory and all the other people in the cancer division, we/news/wp-json/wp/v2/posts/123316/u2019re all working hard on trying to find cures for cancer /news/wp-json/wp/v2/posts/123316/u2014 that we have their back. We/news/wp-json/wp/v2/posts/123316/u2019re doing this because we want to be able to give them hope that maybe we can/news/wp-json/wp/v2/posts/123316/u2019t cure cancer today, but we/news/wp-json/wp/v2/posts/123316/u2019re working hard to find new discoveries that will lead to new treatments for cancer in the future.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Alex Cumming:</news/wp-json/wp/v2/posts/123316//strong> I love what you/news/wp-json/wp/v2/posts/123316/u2019re saying about the hope and the optimism and to know every day students are waking up and going to places like 166su, where their focus is cancer research. And that there/news/wp-json/wp/v2/posts/123316/u2019s this generation of students worldwide who are working, again individual types of cancer, but that every day students are going and that cancer research departments are still prominent and are funded and are in a vital aspect of health departments at universities.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Annette Khaled:</news/wp-json/wp/v2/posts/123316//strong> I love that you said that because that/news/wp-json/wp/v2/posts/123316/u2019s so true. Sometimes you forget because you/news/wp-json/wp/v2/posts/123316/u2019re taking classes and you/news/wp-json/wp/v2/posts/123316/u2019ve got deadlines and you/news/wp-json/wp/v2/posts/123316/u2019ve got to write your papers and your dissertation or whatever. But at the end of the day, what you/news/wp-json/wp/v2/posts/123316/u2019re doing is bringing hope to people.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p>It/news/wp-json/wp/v2/posts/123316/u2019s doing research that/news/wp-json/wp/v2/posts/123316/u2019s going to lead to new advances that one day, it may take five years, it may take 10 years, 20 years ,who knows how much it takes, but that someday you can say, /news/wp-json/wp/v2/posts/123316/u201cI was part of that,/news/wp-json/wp/v2/posts/123316/u201d or /news/wp-json/wp/v2/posts/123316/u201cI was there when that happened, I was contributing to that process./news/wp-json/wp/v2/posts/123316/u201d</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Alex Cumming:</news/wp-json/wp/v2/posts/123316//strong> What/news/wp-json/wp/v2/posts/123316/u2019s so nice, and this goes to most, all forms of medicine, is that a lot of these kids are doing it between the ages of 18 to [when they become] doctor, maybe mid-to-late 20s.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Annette Khaled:</news/wp-json/wp/v2/posts/123316//strong> Or early 20s. Yeah.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Alex Cumming:</news/wp-json/wp/v2/posts/123316//strong> Have their whole lives to work, to develop all these various research and treatments and it/news/wp-json/wp/v2/posts/123316/u2019s so cool. And to repeat what you said, hope, optimism.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p>On top of all your own research and your duties as a tenured professor, you/news/wp-json/wp/v2/posts/123316/u2019re also the head of the Division of Cancer Research here at 166su. What/news/wp-json/wp/v2/posts/123316/u2019s it like to oversee such an important division?</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Annette Khaled:</news/wp-json/wp/v2/posts/123316//strong> Oh that/news/wp-json/wp/v2/posts/123316/u2019s a lot to say in one sentence. I really enjoy working with people and being part of helping to lead the cancer division. There/news/wp-json/wp/v2/posts/123316/u2019s about, I want to say 11 or 12 researchers that fall under that division. It&#8217;s part of what I do every day. It/news/wp-json/wp/v2/posts/123316/u2019s not separate. I do my own research, but I also have that eye on the division as a whole to bring them together. So it really integrates very well with my current duties. I don/news/wp-json/wp/v2/posts/123316/u2019t see it as a separate thing, but it really falls alongside the things that I do every day. I teach students, I teach classes, I run my own lab. But part of that process is also keeping that global idea of how I can help my fellow colleagues in the cancer division also be successful. And so it/news/wp-json/wp/v2/posts/123316/u2019s all aligned together.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Alex Cumming:</news/wp-json/wp/v2/posts/123316//strong> That you have to manage and understand what/news/wp-json/wp/v2/posts/123316/u2019s going on with everybody outside of yourself, but then also focusing on your own work, I can imagine that/news/wp-json/wp/v2/posts/123316/u2019s a lot to juggle at some times.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Annette Khaled:</news/wp-json/wp/v2/posts/123316//strong> Well, like I said, it happens in parallel. We/news/wp-json/wp/v2/posts/123316/u2019re very collaborative. And so, as I said, it/news/wp-json/wp/v2/posts/123316/u2019s not really more work for me. It just aligns with the work that I currently do. The success in my lab extends to the division and the division successes feed back into mine. It/news/wp-json/wp/v2/posts/123316/u2019s become like a synergy. We/news/wp-json/wp/v2/posts/123316/u2019re all in it together. One person/news/wp-json/wp/v2/posts/123316/u2019s success is everybody/news/wp-json/wp/v2/posts/123316/u2019s success.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Alex Cumming:</news/wp-json/wp/v2/posts/123316//strong> I love that. I imagine in a cancer research department egos are probably set aside and there/news/wp-json/wp/v2/posts/123316/u2019s not this competitive drive because one person/news/wp-json/wp/v2/posts/123316/u2019s success is everybody/news/wp-json/wp/v2/posts/123316/u2019s success.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p>I mean, in my own theatrical experience, yeah there/news/wp-json/wp/v2/posts/123316/u2019s egos every now and then. But it/news/wp-json/wp/v2/posts/123316/u2019s like, if you/news/wp-json/wp/v2/posts/123316/u2019re good for the show and the show was good, that/news/wp-json/wp/v2/posts/123316/u2019s on everybody.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Annette Khaled:</news/wp-json/wp/v2/posts/123316//strong> Yeah, we/news/wp-json/wp/v2/posts/123316/u2019re a team. &nbsp;Everybody/news/wp-json/wp/v2/posts/123316/u2019s doing their research and their thing, but cancer is very collaborative. It/news/wp-json/wp/v2/posts/123316/u2019s a field where you really lean a lot on each other. Everybody/news/wp-json/wp/v2/posts/123316/u2019s got an expertise, I don/news/wp-json/wp/v2/posts/123316/u2019t have to be the expert of every single thing. I can go to my colleagues and say, /news/wp-json/wp/v2/posts/123316/u201cI want to do this experiment you/news/wp-json/wp/v2/posts/123316/u2019ve done it in your lab. Can you help me do it in mine?/news/wp-json/wp/v2/posts/123316/u201d And this is, the ideal situation you/news/wp-json/wp/v2/posts/123316/u2019ve got this great team of folks that all have that joint vision of, yeah, we/news/wp-json/wp/v2/posts/123316/u2019re going to cure cancer one day. Not today, maybe, but down the road that/news/wp-json/wp/v2/posts/123316/u2019s our very ambitious goal. But we/news/wp-json/wp/v2/posts/123316/u2019ll help each other today to do the things that we need to do.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Alex Cumming:</news/wp-json/wp/v2/posts/123316//strong> It sounds like collaboration, teamwork and synergy are what helped you balance your responsibilities.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Annette Khaled:</news/wp-json/wp/v2/posts/123316//strong> Exactly. You got it. Exactly.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Alex Cumming:</news/wp-json/wp/v2/posts/123316//strong> That seems to be a running trend here at 166su. With all of the amazing people I/news/wp-json/wp/v2/posts/123316/u2019ve had the pleasure to speak with, is that 166su is just such a, and again this is not a new thought, but it/news/wp-json/wp/v2/posts/123316/u2019s just a great place for collaboration and teamwork are two of the big takeaways that you mentioned.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p>Everybody has their departments, but all the departments work together. And when all the departments are doing is great that just makes 166su look great.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Annette Khaled:</news/wp-json/wp/v2/posts/123316//strong> I don/news/wp-json/wp/v2/posts/123316/u2019t know if it/news/wp-json/wp/v2/posts/123316/u2019s just because of the way /news/wp-json/wp/v2/posts/123316/u2014 we/news/wp-json/wp/v2/posts/123316/u2019re a young institution, right? In many ways, even biomedical research is barely a decade old, so we are still building our reputation. We/news/wp-json/wp/v2/posts/123316/u2019re building our credibility in the state. And that part of that helps us lean on each other more maybe than if we were in a nice established, fully funded institution with all the bells and whistles. Most people can thrive on their own better, but you know here we really rely on each other to help each other move forward.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Alex Cumming:</news/wp-json/wp/v2/posts/123316//strong> That/news/wp-json/wp/v2/posts/123316/u2019s why I love this place. A moment ago, we spoke about my personal experience with breast cancer, how it affected my life in my younger years. Have you been able to meet families of breast cancer patients through your work?</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Annette Khaled:</news/wp-json/wp/v2/posts/123316//strong> Oh, yeah. I work with two very important organizations for breast cancer in the state of Florida and in Orlando. The Florida Breast Cancer Foundation is a fantastic organization of folks, breast cancer survivors, as well as researchers, doctors, all sorts of individuals, who are really focused to eliminate breast cancer for the state of Florida. And so I/news/wp-json/wp/v2/posts/123316/u2019ve been working with that organization for a number of years and really get a chance to interact with all these folks /news/wp-json/wp/v2/posts/123316/u2014 as I said, breast cancer survivors, breast cancer advocates, for folks that go all the way to Tallahassee and just do their best to get funds to help breast cancer survivors and breast cancer patients in the state of Florida, researchers like myself. So that/news/wp-json/wp/v2/posts/123316/u2019s a great organization, the Florida Breast Cancer Foundation.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p>But I also work locally with the Orlando Sports Foundation and they/news/wp-json/wp/v2/posts/123316/u2019re also an organization that/news/wp-json/wp/v2/posts/123316/u2019s led by Alan Gooch, who was one of our first football coaches at 166su. He runs this fantastic foundation that is really trying to use sport and sport venues, like football, golf, even bowling, all these venues to drive awareness for breast cancer and fund breast cancer as well, generate funds for breast cancer. So working through that organization. I/news/wp-json/wp/v2/posts/123316/u2019ve met great people who really have a big heart and want to make an impact in our community.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p>So, like I said, I/news/wp-json/wp/v2/posts/123316/u2019m really blessed to have those two organizations that I can interact with and meet people</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Alex Cumming:</news/wp-json/wp/v2/posts/123316//strong> You/news/wp-json/wp/v2/posts/123316/u2019re wearing the pink, most people won/news/wp-json/wp/v2/posts/123316/u2019t be able to see it, but we know wearing pink to signify, to recognize, to honor the work people have gone through and to recognize the hard work that still goes into breast cancer awareness. And to have individuals that promote breast cancer awareness is so special to see is. That this is not just underground, subculture. It is in the general, it is in the zeitgeist. Again, you run into individuals who have experiences with breast cancer, like myself. Most people would be totally unaware that affected me in my younger years. It/news/wp-json/wp/v2/posts/123316/u2019s not something that since then I often reflect, but it/news/wp-json/wp/v2/posts/123316/u2019s in my memories. And you run into people that you might not realize have had an experience, had a breast cancer scare, had a surgery to maybe remove a piece of themselves. And you don/news/wp-json/wp/v2/posts/123316/u2019t realize that wearing pink is so special because it just, it/news/wp-json/wp/v2/posts/123316/u2019s there, it exists. You want to recognize it, the pink bracelets that individuals wear. When you noticed it on somebody.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Annette Khaled:</news/wp-json/wp/v2/posts/123316//strong> And it/news/wp-json/wp/v2/posts/123316/u2019s so true because it really says, /news/wp-json/wp/v2/posts/123316/u201cWe/news/wp-json/wp/v2/posts/123316/u2019re here, you/news/wp-json/wp/v2/posts/123316/u2019re not alone. This is not a fight you/news/wp-json/wp/v2/posts/123316/u2019re doing by yourself and you/news/wp-json/wp/v2/posts/123316/u2019ve got all of us wearing pink because we all want to be part of that team, that big universal team that goes beyond Orlando beyond Florida./news/wp-json/wp/v2/posts/123316/u201d That really is a global team that works toward, supporting, and helping, and eliminating in the long run breast cancer.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Alex Cumming:</news/wp-json/wp/v2/posts/123316//strong> From the families and the patients that you have met, what have you been able to learn?</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Annette Khaled:</news/wp-json/wp/v2/posts/123316//strong> Well, a lot of how they cope. I remember sitting at a lunch one day and talking to a lady who had breast cancer. She/news/wp-json/wp/v2/posts/123316/u2019s a survivor and she/news/wp-json/wp/v2/posts/123316/u2019s [been] taking treatments for decades that give her hot flashes. Now, you/news/wp-json/wp/v2/posts/123316/u2019re young, you/news/wp-json/wp/v2/posts/123316/u2019re a man, you don/news/wp-json/wp/v2/posts/123316/u2019t know how hot flashes affect women, but I&#8217;m going through that and I can tell you it/news/wp-json/wp/v2/posts/123316/u2019s miserable. And I cannot imagine dealing for the rest of my life with hot flashes, but she has to because of the treatments she/news/wp-json/wp/v2/posts/123316/u2019s getting. And I remember sitting there going like, &#8220;Gosh, I wish I could make a therapeutic this woman could take in place of what she/news/wp-json/wp/v2/posts/123316/u2019s taking right now and help her have a better quality of life so that she/news/wp-json/wp/v2/posts/123316/u2019s not living with these hot flashes.&#8221;</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p>It/news/wp-json/wp/v2/posts/123316/u2019s just things like that. But I found, just interacting with people made me appreciate really how it/news/wp-json/wp/v2/posts/123316/u2019s not just surviving. &nbsp;It/news/wp-json/wp/v2/posts/123316/u2019s about quality of life, and making sure that what I do in my laboratory and the therapeutics and diagnostics that we move forward are always about quality of life as well. We don/news/wp-json/wp/v2/posts/123316/u2019t want to put something out there that is going to make people sick more than they are from the cancer that they/news/wp-json/wp/v2/posts/123316/u2019re dealing with.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Alex Cumming:</news/wp-json/wp/v2/posts/123316//strong> That/news/wp-json/wp/v2/posts/123316/u2019s so special. To touch back on to the young students working to cure breast cancer, everybody has maybe their own motivations and their own stories of what inspires them, but it/news/wp-json/wp/v2/posts/123316/u2019s also this one larger goal.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Annette Khaled:</news/wp-json/wp/v2/posts/123316//strong> Exactly. And I think it/news/wp-json/wp/v2/posts/123316/u2019s important. If I could just make one more plug here. I think it/news/wp-json/wp/v2/posts/123316/u2019s important that as a researcher, it doesn/news/wp-json/wp/v2/posts/123316/u2019t matter what discipline you/news/wp-json/wp/v2/posts/123316/u2019re working in /news/wp-json/wp/v2/posts/123316/u2014 whether it/news/wp-json/wp/v2/posts/123316/u2019s infectious disease or neuroscience, whatever field you/news/wp-json/wp/v2/posts/123316/u2019re in /news/wp-json/wp/v2/posts/123316/u2014 to always connect with the people, right. Connect with individual. You know that if you/news/wp-json/wp/v2/posts/123316/u2019re working in disease, Alzheimer/news/wp-json/wp/v2/posts/123316/u2019s connect with those. You/news/wp-json/wp/v2/posts/123316/u2019re working with infectious disease, connect with people, HIV, because that connection really brings your research home. It really helps you focus your research on things that are going to impact people, not just something that/news/wp-json/wp/v2/posts/123316/u2019s your own. Like you said, ego, right? It/news/wp-json/wp/v2/posts/123316/u2019s something that you/news/wp-json/wp/v2/posts/123316/u2019re doing to do that/news/wp-json/wp/v2/posts/123316/u2019s going to help the community. So I really love, not just for myself but also have my students connect with breast cancer survivors for that reason.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Alex Cumming:</news/wp-json/wp/v2/posts/123316//strong> Humanity, that the individual in that room is not patient number 52. They are, John Doe from Longwood, Florida.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Annette Khaled:</news/wp-json/wp/v2/posts/123316//strong> Exactly.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Alex Cumming:</news/wp-json/wp/v2/posts/123316//strong> I have a personal experience with what you/news/wp-json/wp/v2/posts/123316/u2019re saying. My involvement at 166su I/news/wp-json/wp/v2/posts/123316/u2019m with an organization called Playback 166su, which we began with our focus, it/news/wp-json/wp/v2/posts/123316/u2019s people tell stories and we/news/wp-json/wp/v2/posts/123316/u2019ll present them back through an improvised form. And we started with students and of course, young college students have a lot of feelings. They feel things very strongly, and it was very special to perform back, to get to know my cohort better. But then we transitioned and we work indefinitely with the Aphasia House here in the 166su area. And really the one-on-one experience of people who live life with aphasia it touches you in a way that you don/news/wp-json/wp/v2/posts/123316/u2019t expect going in. You might have an idea, but once you/news/wp-json/wp/v2/posts/123316/u2019ve experienced it firsthand you don/news/wp-json/wp/v2/posts/123316/u2019t forget.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Annette Khaled:</news/wp-json/wp/v2/posts/123316//strong> And I think it helps, put perspective to things. It really helps you say, /news/wp-json/wp/v2/posts/123316/u201cOkay, maybe what I was thinking wasn/news/wp-json/wp/v2/posts/123316/u2019t so bad. My own little problems in my own little world, I can give perspective to them./news/wp-json/wp/v2/posts/123316/u201d</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Alex Cumming:</news/wp-json/wp/v2/posts/123316//strong> It does. It/news/wp-json/wp/v2/posts/123316/u2019s sort of, a humbling, but not in a humbling, /news/wp-json/wp/v2/posts/123316/u201cLike, oh man, now I feel bad./news/wp-json/wp/v2/posts/123316/u201d It&#8217;s a humbling like, /news/wp-json/wp/v2/posts/123316/u201cWow, I get to wake up every day and not worry about these sorts of things./news/wp-json/wp/v2/posts/123316/u201d</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Annette Khaled:</news/wp-json/wp/v2/posts/123316//strong> And in value, when these individuals are waking up every day and they/news/wp-json/wp/v2/posts/123316/u2019re doing their lives and their things, and really the strengths that they have I always admire that tremendously.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Alex Cumming:</news/wp-json/wp/v2/posts/123316//strong> Seriously to go back to another point, we have hope. The students have hope, but the individuals who are living with this day to day, their hope is what I want to believe. Their hope is what inspires the hope of the younger generations to continue to work. Because when they get afflicted by it, they don/news/wp-json/wp/v2/posts/123316/u2019t, sit down and say, /news/wp-json/wp/v2/posts/123316/u201cWell, let me count down the clock./news/wp-json/wp/v2/posts/123316/u201d It/news/wp-json/wp/v2/posts/123316/u2019s, /news/wp-json/wp/v2/posts/123316/u201cNo, I know that somebody is working for me. There/news/wp-json/wp/v2/posts/123316/u2019s somebody out there who has me on their mind./news/wp-json/wp/v2/posts/123316/u201d</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Annette Khaled:</news/wp-json/wp/v2/posts/123316//strong> And getting to a point you addressed earlier about your patient/news/wp-json/wp/v2/posts/123316/u2019s point of view and individuals/news/wp-json/wp/v2/posts/123316/u2019 hope and point of view, your mental wellbeing. If you have hope that whatever treatments, whatever therapy, whatever you/news/wp-json/wp/v2/posts/123316/u2019re going through, you have a chance of doing better because your mental wellbeing is healthy. Right?</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p>And so that/news/wp-json/wp/v2/posts/123316/u2019s why it/news/wp-json/wp/v2/posts/123316/u2019s so critical not just to have the treatments and then whatever you/news/wp-json/wp/v2/posts/123316/u2019re supposed to do, your doctor tells you is critical to do, but also along those same lines, you have the hope, you have the mental wellbeing because those two together /news/wp-json/wp/v2/posts/123316/u2014 the treatments and the mental wellbeing /news/wp-json/wp/v2/posts/123316/u2014 is what/news/wp-json/wp/v2/posts/123316/u2019s going to lead to ultimately a treatment outcome, a success.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Alex Cumming:</news/wp-json/wp/v2/posts/123316//strong> I love it. Do you have any other experiences or stories that keep yourself inspired?</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Annette Khaled:</news/wp-json/wp/v2/posts/123316//strong> Oh, there/news/wp-json/wp/v2/posts/123316/u2019s so many of them. I have to pick and choose.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Alex Cumming:</news/wp-json/wp/v2/posts/123316//strong> Any highlights?</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Annette Khaled:</news/wp-json/wp/v2/posts/123316//strong> It/news/wp-json/wp/v2/posts/123316/u2019s really just being a survivor, and then not knowing if a cancer/news/wp-json/wp/v2/posts/123316/u2019s going to come back. And that/news/wp-json/wp/v2/posts/123316/u2019s the other big thing is /news/wp-json/wp/v2/posts/123316/u2014 somebody tells me, /news/wp-json/wp/v2/posts/123316/u201cI had breast cancer 20 years ago and then it came back and now it/news/wp-json/wp/v2/posts/123316/u2019s metastatic. And now I have five years, survival is really bad at this point, it/news/wp-json/wp/v2/posts/123316/u2019s 20% or less./news/wp-json/wp/v2/posts/123316/u201d So it just talking to patients who have metastatic cancer and the way that they know they have almost a death sentence on their heads and yet they still have the hope, still have that enthusiasm. I/news/wp-json/wp/v2/posts/123316/u2019m going to be here for my grandkids. I/news/wp-json/wp/v2/posts/123316/u2019m going to be here for my daughter/news/wp-json/wp/v2/posts/123316/u2019s wedding. So many of those stores really inspire me and say, what we do every day. What we wake up in the morning, go to the lab, go to work, go to school, whatever we/news/wp-json/wp/v2/posts/123316/u2019re doing, thinking of those people is really what drives a lot of that for me</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Alex Cumming:</news/wp-json/wp/v2/posts/123316//strong> Humanity, the one common that we all have, we/news/wp-json/wp/v2/posts/123316/u2019re all humans.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Annette Khaled:</news/wp-json/wp/v2/posts/123316//strong> Yep. When you/news/wp-json/wp/v2/posts/123316/u2019re faced with a crisis like that humanity is even stronger. It comes out more.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Alex Cumming:</news/wp-json/wp/v2/posts/123316//strong> So I want to move on to this next question of what are some of the biggest mysteries of breast cancer that we&#8217;re still trying to solve?</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Annette Khaled:</news/wp-json/wp/v2/posts/123316//strong> It comes back to what I was telling you, cancer recurrence, why after you/news/wp-json/wp/v2/posts/123316/u2019ve had treatment and the cancer was removed and you got all this therapy and you were given a clean bill of health /news/wp-json/wp/v2/posts/123316/u2014 and then whammo five, 10, 20 years later, it comes back. We really do not know why, what changed. And a lot of times when it comes back, the treatments that work the first time don/news/wp-json/wp/v2/posts/123316/u2019t work anymore. It really is a real challenge for physicians to know what to do for these patients. So that/news/wp-json/wp/v2/posts/123316/u2019s one. And then the other one is the last few years immunotherapy, that/news/wp-json/wp/v2/posts/123316/u2019s basically taking your body/news/wp-json/wp/v2/posts/123316/u2019s immune system and turning it on so it can kill cancer cells, has really been an exciting new research and therapeutic direction and great successes for patients. But it doesn/news/wp-json/wp/v2/posts/123316/u2019t work for all patients. In fact, it works for maybe under 30% of patients. When it does work it/news/wp-json/wp/v2/posts/123316/u2019s amazing, it/news/wp-json/wp/v2/posts/123316/u2019s a cure, but why doesn/news/wp-json/wp/v2/posts/123316/u2019t it work for everybody? That/news/wp-json/wp/v2/posts/123316/u2019s the other big question. Why can/news/wp-json/wp/v2/posts/123316/u2019t we get this immunotherapy that has been so successful in this group of patients to work for everybody? How can a doctor know, do I give my patient immunotherapy or not?</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p>Those are kind of the two big things for me, is that, why does cancer come back and then how do we figure out to give the patients their best treatments?</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Alex Cumming:</news/wp-json/wp/v2/posts/123316//strong> Those are both two things that are, what a wild thing to think about. So what advice would you give to somebody who wants to do what you do?</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Annette Khaled:</news/wp-json/wp/v2/posts/123316//strong> Oh, you have to have a passion for it. Doing research is not something that you can just open the door and do. I think you really have to have a passion and a love for discovery and have a thick skin that you can put up with disappointment and struggle and the negative parts of it. But always have that passion for discovery and know that those moments when you have that, /news/wp-json/wp/v2/posts/123316/u201cAha, well we just discovered something really cool./news/wp-json/wp/v2/posts/123316/u201d To be able to live for those moments and enjoy them. So I can say it/news/wp-json/wp/v2/posts/123316/u2019s a vocation almost to do research.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Alex Cumming:</news/wp-json/wp/v2/posts/123316//strong></news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Annette Khaled:</news/wp-json/wp/v2/posts/123316//strong> Yes, endurance, lots of things that go with it /news/wp-json/wp/v2/posts/123316/u2014 and surprisingly optimism. I think you also have to have an optimistic mind frame because if you/news/wp-json/wp/v2/posts/123316/u2019re pessimistic and you look always at the hole and not the donut, you/news/wp-json/wp/v2/posts/123316/u2019re going to struggle. I think having a little bit of optimism is always good.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Alex Cumming:</news/wp-json/wp/v2/posts/123316//strong> Yeah. I believe that translates to most everything that people do. Is there a profession you can have where you can just be a pessimist? If you/news/wp-json/wp/v2/posts/123316/u2019re like a critic?</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Annette Khaled:</news/wp-json/wp/v2/posts/123316//strong> Yeah, you can be a critic. I think there/news/wp-json/wp/v2/posts/123316/u2019s some professions that work well with that, but I would say definitely in ours, because we have so much pessimism and there/news/wp-json/wp/v2/posts/123316/u2019s so much negativity sometimes associated with doing medical research that I think, every little bit of optimism you can bring to it is important.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Alex Cumming:</news/wp-json/wp/v2/posts/123316//strong> Totally. So what/news/wp-json/wp/v2/posts/123316/u2019s one thing that you&#8217;re still hoping to do here at 166su, and then on a personal level?</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Annette Khaled:</news/wp-json/wp/v2/posts/123316//strong> Actually those two things are tied together. We/news/wp-json/wp/v2/posts/123316/u2019re building a new cancer center and this has been something that/news/wp-json/wp/v2/posts/123316/u2019s been in the works for now going on three years. I/news/wp-json/wp/v2/posts/123316/u2019m hoping to be able to be part of the process that we build our cancer center and hopefully make it a place that/news/wp-json/wp/v2/posts/123316/u2019s not only a place for students, a place for professors, like myself, to do research, a place for patients to come and get cutting-edge therapies. Really a place where all that/news/wp-json/wp/v2/posts/123316/u2019s integrated, where we really have a flow of knowledge from all these levels of students, to professors, to patients, to doctors, to everybody involved in treating a cancer patient.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p>So really it/news/wp-json/wp/v2/posts/123316/u2019s ambitious, but I do see hope one day that we can be sitting here maybe 10 years down the road and saying, /news/wp-json/wp/v2/posts/123316/u201cYeah, that Lake Nona Cancer Center that/news/wp-json/wp/v2/posts/123316/u2019s one of the top 10 cancer centers in the country for everybody to come to./news/wp-json/wp/v2/posts/123316/u201d</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Alex Cumming:</news/wp-json/wp/v2/posts/123316//strong> I/news/wp-json/wp/v2/posts/123316/u2019m looking forward to it. I love the sound of a place where just knowledge healing growth is all just wrapped into one, based out of here in central Florida.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Annette Khaled:</news/wp-json/wp/v2/posts/123316//strong> And has that unique 166su culture, right? We were talking about earlier that collaborative culture that infuses our cancer system.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Alex Cumming:</news/wp-json/wp/v2/posts/123316//strong> True that. I think everything we spoke about today can be found at 166su, the collaboration, the teamwork, the optimism, the growth for the future, the humanity, it/news/wp-json/wp/v2/posts/123316/u2019s all here at 166su.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p>So Annette, I want to say thank you so much for speaking with me today. loved our conversation. Thank you for letting me speak about my own personal experiences and for sharing your own experiences. It/news/wp-json/wp/v2/posts/123316/u2019s been such a pleasure to get to learn more about something that I&#8217;m aware of, I have memories of, but to dive a little deeper into it. To get a better understanding of it. So it/news/wp-json/wp/v2/posts/123316/u2019s been a pleasure to get to speak with you and thank you for coming on.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Annette Khaled:</news/wp-json/wp/v2/posts/123316//strong> Well, thank you for asking me. I really enjoyed it. And I&#8217;m so happy to hear about your grandmother.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Alex Cumming:</news/wp-json/wp/v2/posts/123316//strong> She/news/wp-json/wp/v2/posts/123316/u2019s still here. I&#8217;m certain she/news/wp-json/wp/v2/posts/123316/u2019ll love this episode.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Annette Khaled:</news/wp-json/wp/v2/posts/123316//strong> Wish her well for me.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Alex Cumming:</news/wp-json/wp/v2/posts/123316//strong> I certainly shall. Thank you.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Annette Khaled:</news/wp-json/wp/v2/posts/123316//strong> Okay. Thank you. Take care.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<p><strong>Alex Cumming:</news/wp-json/wp/v2/posts/123316//strong> Hey, thanks for listening. I/news/wp-json/wp/v2/posts/123316/u2019ll see you, you, on the next episode of the Kights Do That podcast. If you/news/wp-json/wp/v2/posts/123316/u2019re doing something cool, whether that/news/wp-json/wp/v2/posts/123316/u2019s at 166su or somewhere, you took 166su that we should know about. Send us an email <a href=/news/wp-json/wp/v2/posts/123316/"mailto:socialmedia@ucf.edu/news/wp-json/wp/v2/posts/123316/">socialmedia@ucf.edu</news/wp-json/wp/v2/posts/123316//a>, and maybe we/news/wp-json/wp/v2/posts/123316/u2019ll see you on an episode in the future. Go Knights and Charge On.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n","protected":false},"excerpt":{"rendered":"<p>Annette Khaled, a College of Medicine professor and the head of the Division of Cancer Research at 166su discusses her expertise and explains some of the biggest mysteries of breast cancer that we/news/wp-json/wp/v2/posts/123316/u2019re still trying to solve.</news/wp-json/wp/v2/posts/123316//p>/news/wp-json/wp/v2/posts/123316/n<figure class=/news/wp-json/wp/v2/posts/123316/"wp-block-audio/news/wp-json/wp/v2/posts/123316/"><noscript><audio 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